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Journal of Clinical Microbiology, August 2002, p. 3068-3070, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.3068-3070.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Emergence of an Influenza B Virus with Antigenic Change

Department of Parasitic Agents, Kobe Institute of Health, 4-6, Minatojima-nakamachi, Kobe 650-0046,¹ Department of Clinical Pathology, Osaka Medical College, Takatsuki 569-8686, Japan²

Received 3 January 2002/ Returned for modification 10 February 2002/ Accepted 18 May 2002

Influenza B virus Yamagata group strains, isolated in the 2000 to 2001 influenza epidemic season, reacted poorly to the polyclonal ferret sera prepared against strains isolated earlier. The results of genetic analysis clarified that a point mutation of the nucleotide at position 126 in the HA1 region and the corresponding one-amino-acid substitution altered viral antigenicity.

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