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Journal of Clinical Microbiology, September 2002, p. 3493-3496, Vol. 40, No. 9
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.9.3493-3496.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Rate of Hepatitis B Virus Infection in Pregnant Women Determined by a Monoclonal Hepatitis B Surface Antigen Immunoassay

Melissa G. Gotstein,1 Paula M. Aide,1 Paul F. Coleman,2 and Mark R. Sanborn3*

Hepatitis Business Team,1 Core R&D,2 Scientific Affairs,Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, Illinois3

Received 14 January 2002/ Returned for modification 18 May 2002/ Accepted 14 June 2002

The rate of HBsAg in 6,976 B-human chorionic gonadotropin (B-hCG)-positive specimens, as determined by the Auszyme Monoclonal assay (Abbott Laboratories, Abbott Park, Ill.), was 0.56% (39 of 6,986 repeatedly reactive [RR] and confirmed-positive specimens). All RR and confirmed specimens were hepatitis B virus positive by at least one additional test, yielding an assay specificity of 99.96%. The findings argue against unique attributes in the pregnant population that might produce inaccurate assay results.

* Corresponding author. Mailing address: Scientific Affairs Manager, Dept. 02RE, AP6C, 100 Abbott Park Rd., Abbott Park, IL 60064-6081. Phone: (847) 938-0320. Fax: (847) 935-2440. E-mail: mark.sanborn{at}Abbott.com.

Journal of Clinical Microbiology, September 2002, p. 3493-3496, Vol. 40, No. 9
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.9.3493-3496.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2002 by the American Society for Microbiology. All rights reserved.