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Journal of Clinical Microbiology, November 2003, p. 5344-5346, Vol. 41, No. 11
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.11.5344-5346.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Relationship of Relapsing Hip Prosthesis Infection by Staphylococcus aureus with Gamma Interferon Deficiency

Amélie Honstettre,1 Jean-Louis Mège,1 Gérard Lina,2 Jean-Manuel Aubaniac,3 and Michel Drancourt1*

Unité des Rickettsies CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée,1 AP-HM Sainte Marguerite, Service de Chirurgie Orthopédique, Hôpital Sainte-Marguerite, Assistance-Publique—Hôpitaux de Marseille, Marseille,3 Centre National de Référence des Toxémies Staphylococciques, EA1655, Faculté de Médecine Laennec, Lyon, France2

Received 16 May 2003/ Returned for modification 8 June 2003/ Accepted 14 August 2003

Infections complicate 0.5 to 1% of surgeries for total hip prostheses. Staphylococcus species are the most common etiological agents. The role of host factors in the persistence of such infections despite appropriate therapy has yet to be determined. We report the defective immune response characterized by oversecretion of tumor necrosis factor and interleukin 10 and by undersecretion of gamma interferon in such a patient. Further study may determine the prevalence of such deficits and the most appropriate therapy for these patients.

* Corresponding author. Mailing address: Unité des Rickettsies, Faculté de Médecine, Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France. Phone: 33 04 91 32 43 75. Fax: 33 04 91 38 77 72. E-mail: michel.drancourt{at}medecine.univ-mrs.fr.

Journal of Clinical Microbiology, November 2003, p. 5344-5346, Vol. 41, No. 11
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.11.5344-5346.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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