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Journal of Clinical Microbiology, October 2008, p. 3426-3428, Vol. 46, No. 10
0095-1137/08/$08.00+0     doi:10.1128/JCM.01455-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Evaluation of Methods for Rapid Detection of Resistance to Isoniazid and Rifampin in Mycobacterium tuberculosis Isolates Collected in the Caribbean

Department of Para-Clinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago,¹ Caribbean Epidemiology Centre, Jamaica Boulevard, Port of Spain, Trinidad and Tobago,² Institut Pasteur de la Guadeloupe, Abymes, Guadeloupe³

Received 29 July 2008/ Accepted 2 August 2008

The rapid identification of drug-resistant strains of Mycobacterium tuberculosis is crucial for the timely initiation of appropriate antituberculosis therapy. The performance of the Genotype MTBDRplus assay was compared with that of the Bactec 460 TB system, a "gold standard" culture-based method. The Genotype MTBDRplus assay was quicker and more cost-effective for the detection of rifampin resistance, but it was not as good for the detection of isoniazid-resistant strains in our setting.

Published ahead of print on 13 August 2008.