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Journal of Clinical Microbiology, February 2008, p. 757-758, Vol. 46, No. 2
0095-1137/08/$08.00+0     doi:10.1128/JCM.01729-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Early Impairment of Gut Function and Gut Flora Supporting a Role for Alteration of Gastrointestinal Mucosa in Human Immunodeficiency Virus Pathogenesis{triangledown}

Andrea Gori,1,2* Camilla Tincati,2 Giuliano Rizzardini,3 Carlo Torti,4 Tiziana Quirino,5 Monique Haarman,6 Kaouther Ben Amor,6 Jacqueline van Schaik,6 Aldwin Vriesema,6 Jan Knol,6 Giulia Marchetti,7 Gjalt Welling,8 and Mario Clerici9

Division of Infectious Diseases, Department of Internal Medicine, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy,1 Department of Internal Medicine, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy,2 1st Division of Infectious Diseases, Luigi Sacco Hospital, Milan, Italy,3 Clinic of Infectious Diseases, University of Brescia, Brescia, Italy,4 Infectious Diseases Unit, Busto Arsizio Hospital, Busto Arsizio, Italy,5 Numico Research BV, Wageningen, The Netherlands,6 Department of Clinical Science, Luigi Sacco Hospital, University of Milan, Milan, Italy,7 Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands,8 Department of Science Technology Biomedicine, University of Milan, Milan, Italy9

Received 30 August 2007/ Returned for modification 8 October 2007/ Accepted 29 November 2007

Our results show that impairment of the gastrointestinal tracts in human immunodeficiency virus (HIV)-positive patients is present in the early phases of HIV disease. This impairment is associated with alterations in gut microbiota and intestinal inflammatory parameters. These findings support the hypothesis that alterations at the gastrointestinal-tract level are a key factor in HIV pathogenesis.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Internal Medicine, San Gerardo Hospital, University of Milano-Bicocca, Via Solferino 16-20052, Milan, Italy. Phone: 39 039 2333794. Fax: 39 039 2333898. E-mail: andrea.gori{at}unimib.it

{triangledown} Published ahead of print on 19 December 2007.

Journal of Clinical Microbiology, February 2008, p. 757-758, Vol. 46, No. 2
0095-1137/08/$08.00+0     doi:10.1128/JCM.01729-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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