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Journal of Clinical Microbiology, March 2008, p. 1076-1080, Vol. 46, No. 3
0095-1137/08/$08.00+0     doi:10.1128/JCM.02065-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Major Uropathogenic Escherichia coli Strain Isolated in the Northwest of England Identified by Multilocus Sequence Typing{triangledown}

Siu Ha Lau,1,3 Suganya Reddy,2 John Cheesbrough,2 Frederick J. Bolton,3 Geraldine Willshaw,4 Tom Cheasty,4 Andrew J. Fox,3 and Mathew Upton1*

Department of Medical Microbiology, School of Medicine, University of Manchester, Clinical Sciences Building, Manchester Royal Infirmary, Manchester M13 9WL, United Kingdom,1 Preston Microbiology Services, Royal Preston Hospital, Lancashire Teaching Hospitals NHS Foundation Trust, Sharoe Green Lane, Preston, Lancashire PR2 9HT, United Kingdom,2 Health Protection Agency North West Laboratory, Clinical Science Building, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom,3 Escherichia, Shigella, Yersinia, and Vibrio Reference Unit, Laboratory of Enteric Pathogens, Centre for Infections, 61 Colindale Avenue, London NW9 5HT, United Kingdom4

Received 24 October 2007/ Returned for modification 10 December 2007/ Accepted 2 January 2008

A total of 88 uropathogenic Escherichia coli isolates, including 68 isolates from urine and 20 isolates from blood, were characterized by multilocus sequence typing (MLST). MLST has identified an important genetic lineage of E. coli, designated sequence type 131 (ST-131), represented by 52 of these isolates, 51 of which were resistant to extended-spectrum cephalosporins. ST-131 appears to be a drug-resistant uropathogenic strain of E. coli responsible for causing urinary tract infections and bacteremia and is widely disseminated among both community and hospital patients from different geographical areas in the northwest of England. Application of MLST has helped to define the population biology which may underpin the epidemiology of pathogenic E. coli strains. The portability of MLST allows the accurate monitoring of this antibiotic-resistant uropathogenic strain of E. coli and will enhance surveillance for this important group of organisms.

* Corresponding author. Mailing address: Department of Medical Microbiology, School of Medicine, University of Manchester, Clinical Sciences Building 1, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom. Phone: 44 161 8828. Fax: 44 161 276 8826. E-mail: m.upton{at}manchester.ac.uk

{triangledown} Published ahead of print on 23 January 2008.

Journal of Clinical Microbiology, March 2008, p. 1076-1080, Vol. 46, No. 3
0095-1137/08/$08.00+0     doi:10.1128/JCM.02065-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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