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Journal of Clinical Microbiology, April 2008, p. 1541-1544, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.00187-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Variation of a Newcastle Disease Virus Hemagglutinin-Neuraminidase Linear Epitope{triangledown}

Sun-Hee Cho,1,{dagger} Hyuk-Joon Kwon,3* Tae-Eun Kim,3 Jae-Hong Kim,1,3 Han-Sang Yoo,2,3 and Sun-Joong Kim1,3,{dagger}

Laboratory of Avian Diseases,1 Department of Infectious Diseases, College of Veterinary Medicine and BK21 for Veterinary Science,2 Zoonotic Disease Institute, Seoul National University, Seoul 151-742, South Korea3

Received 29 January 2008/ Accepted 1 February 2008

Fifty-six Newcastle disease virus strains collected from 2000 to 2006 could be grouped into subgenotype VIId. However, they displayed cumulative mutations in and around the linear epitope of hemagglutinin-neuraminidase (residues 345 to 353) with time. The antigenicities of the variants that became predominant in Korea differ from each other and from the wild type.


* Corresponding author. Mailing address: Zoonotic Disease Institute, Seoul National University, San 56-1, Shillim-Dong, Gwanak-Gu, Seoul 151-742, South Korea. Phone: 82 2 880 1288. Fax: 82 2 885 6614. E-mail: kwonhj01{at}snu.ac.kr

{triangledown} Published ahead of print on 13 February 2008.

{dagger} Present address: BioPOA Co., 441-853 Suwon, Gyeonggi-Do, South Korea.


Journal of Clinical Microbiology, April 2008, p. 1541-1544, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.00187-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.




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