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Journal of Clinical Microbiology, June 2008, p. 1927-1929, Vol. 46, No. 6
0095-1137/08/$08.00+0     doi:10.1128/JCM.00279-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Caspofungin Disk Diffusion Breakpoints and Quality Control

The Clinical Microbiology Institute, 9725 SW Commerce Circle, Wilsonville, Oregon 97070

Received 11 February 2008/ Returned for modification 11 March 2008/ Accepted 2 April 2008

Interpretive disk diffusion breakpoints for caspofungin are proposed by evaluating 762 isolates of Candida spp., representing 10 different species obtained as part of the caspofungin clinical trials. Standardized broth microdilution reference tests were compared to the zone diameters observed with 5-µg caspofungin disks produced by two different disk manufacturers. Disk diffusion breakpoints of 11 mm for susceptible are proposed. Compared to results from MIC testing, these zone diameters produced error rates that were 0.3% for all categories. In addition, an eight-laboratory disk diffusion quality control (QC) study was performed, and QC ranges are proposed for the four QC strains recommended by the CLSI.

Published ahead of print on 9 April 2008.