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Journal of Clinical Microbiology, September 2008, p. 2874-2878, Vol. 46, No. 9
0095-1137/08/$08.00+0     doi:10.1128/JCM.00074-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Identification of Enteroviruses in Naturally Infected Captive Primates{triangledown}

W. Allan Nix,1 Baoming Jiang,2 Kaija Maher,1 Elizabeth Strobert,3 and M. Steven Oberste1*

Polio and Picornavirus Laboratory Branch,1 Gastroenteritis and Respiratory Virus Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia,2 Yerkes National Primate Research Center, Emory University, Atlanta, Georgia3

Received 14 January 2008/ Returned for modification 6 March 2008/ Accepted 22 June 2008

In a recent study, we investigated cases of diarrheal disease among monkeys at a U.S. primate center. In that study, enteroviruses were detected in a high proportion of the fecal specimens tested. To determine whether the enterovirus detections represented the circulation of one or more simian enteroviruses within the colony or the transmission of human enteroviruses from animal handlers, we determined in the present study the serotype identity of each virus by reverse transcription-PCR and sequencing of a portion of the VP1 gene, a region whose sequence corresponds to antigenic type. Enteroviruses were identified in 37 of 56 specimens (66%), 30 of 40 rhesus macaques, 5 of 11 pigtail macaques, 2 of 4 sooty mangabeys, and 0 of 1 chimpanzee. No previously known human viruses were detected. Three previously known simian enterovirus serotypes—SV6, SV19, and SV46—were among the viruses identified, but more than half of the identified viruses were previously unknown; these have been assigned as new types: EV92 and EV103.

* Corresponding author. Mailing address: Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop G-17, Atlanta, GA 30333. Phone: (404) 639-5497. Fax: (404) 639-4011. E-mail: soberste{at}cdc.gov

{triangledown} Published ahead of print on 2 July 2008.

Journal of Clinical Microbiology, September 2008, p. 2874-2878, Vol. 46, No. 9
0095-1137/08/$08.00+0     doi:10.1128/JCM.00074-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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