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J. Clin. Microbiol. doi:10.1128/JCM.01512-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Dynamics of the mucosa-associated flora in ulcerative colitis during remission and clinical relapse

Institute for Clinical Molecular Biology, Christian-Albrechts-University (CAU) Kiel, Schittenhelmstr. 12, 24105 Kiel, Germany; Clinic for General Internal Medicine, University-Hospital Schleswig-Holstein (UKSH), Campus Kiel, Schittenhelmstr. 12, 24105 Kiel, Germany; St. Mark's Hospital, Watford Road, Harrow, Middlesex, HA1 3UJ, London, UK; Institute for Medical Informatics and Statistics, Christian-Albrechts-University (CAU) Kiel, Brunswikerstr. 10, 24105 Kiel, Germany

^* To whom correspondence should be addressed. Email: kamm{at}ic.ac.uk.

	Abstract

The colonic mucosa-associated flora (MAF) in patients with active ulcerative colitis (n=13) was investigated by 16S rDNA signatures during remission and relapse against controls (n=5). Baseline reduction, temporal instability and decrease of bacterial richness towards relapse were observed in UC patients, whereas the MAF in controls is stable over time.