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Journal of Clinical Microbiology, December 2003, p. 5577-5581, Vol. 41, No. 12
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.12.5577-5581.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Borna Disease Virus RNA in Immunocompromised Patients in Southwestern France

Emmanuelle Cotto,1* Didier Neau,2 Martine Cransac-Neau,3 Marc Auriacombe,4 Jean-Luc Pellegrin,5 Jean-Marie Ragnaud,2 Anne-Marie Fillet,6 Magali Belnard,6 Hervé Fleury,1 and Marie-Edith Lafon1

Laboratoire de Virologie, Université Bordeaux 2, and Centre Hospitalier Régional de Bordeaux,1 Fédération de Pathologies Infectieuses,2 Service de Transplantation Hépatique, Hôpital Pellegrin,3 Service de Psychiatrie, Université Bordeaux 2 and Hôpital Charles Perrens, 33076 Bordeaux,4 Service de Médecine Interne, Hôpital du Haut Lévêque, 33600 Pessac,5 Laboratoire de Virologie, Centre Hospitalier Universitaire Pitié Salpétrière, AP-HP, 75015 Paris, France6

Received 2 April 2003/ Returned for modification 2 August 2003/ Accepted 13 September 2003

Borna disease virus (BDV) is a neurotropic RNA virus with a wide host range. Human infections, although controversial, have been described in Europe, Asia, and the United States. The present study investigated the existence of BDV infections in immunocompromised human beings, namely, 82 human immunodeficiency virus (HIV)-infected and 80 therapeutically immunosuppressed patients. BDV p40 RNAs were detected in peripheral white blood cells with reverse transcription-nested PCR and hybridization in, respectively, 11 (13.41%) and 1 (1.25%) of the two groups of patients. BDV p24 RNAs were identified in only one of those. BDV RNA was detected in the absence of any neuropsychiatrical illness, suggesting that BDV infections may occur in asymptomatic carriers. The severity and particularity of cellular immunosuppression could explain the significantly increased detection of BDV RNA in HIV-infected patients.

* Corresponding author. Mailing address: Laboratoire de Virologie, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux, France. Phone: 33 5 57 57 13 63. Fax: 33 5 56 99 11 40. E-mail: emmanuelle.cotto{at}viro.u-bordeaux2.fr.

Journal of Clinical Microbiology, December 2003, p. 5577-5581, Vol. 41, No. 12
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.12.5577-5581.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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